Seten is a tool for systematic identification and comparison of processes, phenotypes and diseases associated with RNA-binding proteins from condition-specific CLIP-seq profiles. Seten is a web-based as well as a command line tool which can identify and compare processes, phenotypes and diseases associated with RBPs from condition-specific CLIP-seq profiles. Seten currently provides precomputed results for more than 150 CLIP-seq datasets and can be used to analyze other kinds of binding profile data such as ChIP-seq data.